Cleveland Clinic, Glickman Urological & Kidney Institute, Cleveland, OH, USA.
Advanced Platform Technology Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Nat Rev Urol. 2019 May;16(5):291-301. doi: 10.1038/s41585-019-0175-5.
Urodynamic studies are a key component of the clinical evaluation of lower urinary tract dysfunction and include filling cystometry, pressure-flow studies, uroflowmetry, urethral function tests and electromyography. However, pitfalls of traditional urodynamics include physical and emotional discomfort, artificial test conditions with catheters and rapid retrograde filling of the bladder, which result in variable diagnostic accuracy. Ambulatory urodynamic monitoring (AUM) uses physiological anterograde filling and, therefore, offers a longer and more physiologically relevant evaluation. However, AUM methods rely on traditional catheters and pressure transducers and do not measure volume continuously, which is required to provide context for pressure changes. Novel telemetric AUM (TAUM) methods that use wireless, catheter-free, battery-powered devices to monitor bladder pressure and volume while patients carry out their daily activities are currently being investigated. TAUM devices under current development are innovating in the areas of remote monitoring, rechargeable energy sources, device deployment and retrieval and materials engineering to provide increased diagnostic accuracy and improved comfort for patients with incontinence or voiding dysfunction. These devices hold promise for improving the diagnosis and management of patients with lower urinary tract disorders.
尿动力学研究是下尿路功能障碍临床评估的一个关键组成部分,包括充盈性膀胱测压、压力-流率研究、尿流率测定、尿道功能测试和肌电图。然而,传统尿动力学的缺陷包括物理和情感上的不适、带有导管的人为测试条件以及膀胱快速逆行填充,这导致诊断准确性存在差异。动态尿动力学监测(AUM)使用生理顺行填充,因此提供了更长时间且更具生理相关性的评估。然而,AUM 方法依赖于传统的导管和压力传感器,并且不能连续测量体积,这对于提供压力变化的背景是必需的。目前正在研究使用无线、无导管、电池供电的设备来监测膀胱压力和体积的新型遥测动态尿动力学监测(TAUM)方法,这些设备在远程监测、可充电能源、设备部署和检索以及材料工程等领域进行创新,以提供更高的诊断准确性和患者舒适度,从而改善尿失禁或排尿功能障碍患者的诊断和管理。这些设备有望改善下尿路疾病患者的诊断和管理。