Zeisel Steven H
Nutrition Research Institute, The University of North Carolina at Chapel Hill, Kannapolis, NC, United States.
Front Genet. 2019 Mar 18;10:200. doi: 10.3389/fgene.2019.00200. eCollection 2019.
Nutrients and food-derived bioactive molecules must transit complex metabolic pathways, and these pathways vary between people. Metabolic heterogeneity is caused by genetic variation, epigenetic variation, differences in microbiome composition and function, lifestyle differences and by variation in environmental exposures. This review discusses a number of these sources of metabolic heterogeneity and presents some of the research investments that will be needed to make applications of precision nutrition practical.
营养素和食物衍生的生物活性分子必须经过复杂的代谢途径，而且这些途径因人而异。代谢异质性是由基因变异、表观遗传变异、微生物群组成和功能的差异、生活方式差异以及环境暴露差异引起的。本综述讨论了代谢异质性的一些来源，并介绍了为使精准营养的应用切实可行而需要进行的一些研究投入。
