蛋白尿在子痫前期中的重要性及其对孕产妇和新生儿结局的预测作用。
The importance of proteinuria in preeclampsia and its predictive role in maternal and neonatal outcomes.
作者信息
Tanacan Atakan, Fadiloglu Erdem, Beksac Mehmet Sinan
机构信息
a Division of Perinatology, Department of Obstetrics and Gynecology , Hacettepe University , Ankara , Turkey.
出版信息
Hypertens Pregnancy. 2019 May;38(2):111-118. doi: 10.1080/10641955.2019.1590718. Epub 2019 Apr 2.
OBJECTIVE
To evaluate impact of 24-h proteinuria level in preeclampsia on maternal/perinatal outcomes.
METHODS
Singleton pregnancies with preeclampsia delivered after 24 weeks of gestation were included. Patients were divided into mild (0.3 to <2 g) (n=72), severe (2 to <5 g) (n=30), and massive (≥5 g) (n=24) proteinuria groups, and cut-off values of 24-h proteinuria for composite adverse maternal and neonatal outcomes were calculated.
RESULTS
Twenty-four hour proteinuria level cut-offs for composite adverse outcomes were 3275 mg (72.2% sensitivity, 85.6% specificity) and 2395 mg (72.7% sensitivity, 78% specificity) respectively.
CONCLUSION
Severe and massive proteinuria were related to poor maternal, perinatal, and neonatal outcomes.
目的
评估子痫前期24小时蛋白尿水平对孕产妇/围产儿结局的影响。
方法
纳入妊娠24周后分娩的单胎子痫前期患者。患者被分为轻度（0.3至<2g）（n = 72）、重度（2至<5g）（n = 30）和大量蛋白尿组（≥5g）（n = 24），并计算孕产妇和新生儿复合不良结局的24小时蛋白尿临界值。
结果
复合不良结局的24小时蛋白尿水平临界值分别为3275mg（敏感性72.2%，特异性85.6%）和2395mg（敏感性72.7%，特异性78%）。
结论
重度和大量蛋白尿与孕产妇、围产儿及新生儿不良结局相关。
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