人类和小鼠朊病毒蛋白基因在同源染色体上的定位。
Assignment of the human and mouse prion protein genes to homologous chromosomes.
作者信息
Sparkes R S, Simon M, Cohn V H, Fournier R E, Lem J, Klisak I, Heinzmann C, Blatt C, Lucero M, Mohandas T
出版信息
Proc Natl Acad Sci U S A. 1986 Oct;83(19):7358-62. doi: 10.1073/pnas.83.19.7358.
Abstract
Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12----pter. Our results should lead to studies of genetic loci syntenic with the PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.
摘要
纯化的瘙痒病朊病毒制剂含有一种主要的大分子，称为朊病毒蛋白（PrP）。编码PrP的基因在正常动物和人类中都能找到，但不在感染性颗粒中。利用体细胞杂种技术，将PrP基因定位于人类20号染色体和相应的小鼠2号染色体上。原位杂交研究将人类PrP基因定位到20p12----pter带。我们的研究结果将有助于对与PrP基因同线的基因座进行研究，这些基因座可能在朊病毒疾病或其他退行性神经疾病的发病机制中发挥作用。
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