健康供体的低密度和高密度脂蛋白作用下，洗涤后的人血小板中血栓素A2（TXA2）的生成。

Thromboxane A2 (TXA2) formation by washed human platelets under the influence of low and high density lipoproteins from healthy donors.

作者信息

Beitz J, Mest H J

出版信息

Prostaglandins Leukot Med. 1986 Aug;23(2-3):303-9. doi: 10.1016/0262-1746(86)90197-6.

Abstract

Low density lipoprotein (LDL) stimulates TXA2 formation (measured as malondialdehyde) in washed human platelets with active cyclooxygenase, whereas high density lipoprotein (HDL) does not show any influence on TXA2 formation in this system. These results support the hypothesis that the proaggregatory action of a high plasma LDL concentration may be mediated by modification in the biosynthesis of eicosanoids. The mode of action of lipoproteins is discussed.

摘要

低密度脂蛋白（LDL）可刺激具有活性环氧化酶的洗涤过的人血小板中血栓素A2（以丙二醛衡量）的形成，而高密度脂蛋白（HDL）在该系统中对血栓素A2的形成没有任何影响。这些结果支持了以下假说：高血浆LDL浓度的促聚集作用可能是由类花生酸生物合成的改变介导的。文中讨论了脂蛋白的作用方式。