老年帕金森病：左旋多巴/苄丝肼联合治疗的长期疗效研究
Parkinson's disease in the elderly: a long-term efficacy study of levodopa/benserazide combination therapy.
作者信息
Mondal B K, Mondal K N
出版信息
Pharmatherapeutica. 1986;4(9):571-6.
An open study was carried out in 60 elderly patients with Parkinson's disease to assess the efficacy and tolerance of long-term treatment with levodopa/benserazide combination therapy. Patients were treated for periods up to 2 years, doses being titrated to the lowest required to bring about adequate relief of symptoms. The mean daily dose ranged from 165 mg on entry to 199 mg in the 43 patients assessed at 24 months. The results showed that treatment provided lasting therapeutic benefits for approximately three-quarters of the study population with a low incidence of side-effects.
对60例老年帕金森病患者进行了一项开放性研究，以评估左旋多巴/苄丝肼联合疗法长期治疗的疗效和耐受性。患者接受治疗的时间长达2年，剂量滴定至能充分缓解症状所需的最低剂量。在24个月时评估的43例患者中，平均每日剂量从入组时的165毫克到199毫克不等。结果表明，治疗为大约四分之三的研究人群提供了持久的治疗益处，且副作用发生率较低。
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