Feldman J M
Gastroenterology. 1978 Dec;75(6):1109-14.
The urinary excretion of 5-hydroxyindoleacetic acid, 5-hydroxytryptophan, serotonin, tryptamine, and tyramine and the serum serotonin concentration were determined in 38 consecutive patients with metastatic carcinoid tumors. Four of the 23 patients with the carcinoid syndrome (15%) had markedly elevated excretion of 5-hydroxytryptophan. None of the patients had markedly elevated excretion of tryptamine or tyramine; a substantial number of patients had moderately low urinary excretion of these amines. All of the patients with the carcinoid syndrome had elevated urinary 5-hydroxyindoleacetic acid excretion; 2 of these patients had normal serum serotonin concentrations, suggesting that quantitative 5-hydroxyindoleacetic acid excretion is the most reliable test for the carcinoid syndrome. Although tryptamine secretion by carcinoid tumors is rare, 5-hydroxytryptophan secretion may be more common than is recognized.
对38例连续性转移性类癌瘤患者测定了5-羟吲哚乙酸、5-羟色氨酸、血清素、色胺和酪胺的尿排泄量以及血清血清素浓度。23例类癌综合征患者中有4例（15%）5-羟色氨酸排泄量显著升高。所有患者的色胺或酪胺排泄量均未显著升高；相当多患者这些胺类的尿排泄量适度降低。所有类癌综合征患者的尿5-羟吲哚乙酸排泄量均升高；其中2例患者血清血清素浓度正常，提示5-羟吲哚乙酸排泄量的定量测定是类癌综合征最可靠的检测方法。虽然类癌瘤分泌色胺很少见，但5-羟色氨酸的分泌可能比公认的更常见。
