Hardin T C, Page C P, Schwesinger W H
Surg Gynecol Obstet. 1986 Oct;163(4):359-62.
The albumin deficit (AD) of 13 malnourished patients with serum albumin concentrations (SAC) of less than 3.0 grams per deciliter was estimated using a simple equation. The AD was replaced over a period of 24 to 72 hours as a component of the formulation of total parenteral nutrition (TPN). AD was estimated assuming a volume of distribution of 3 deciliters per kilogram of actual body weight and a minimum acceptable SAC of 3.5 grams per deciliter. The mean AD was 200 +/- 94 grams (mean +/- standard deviation), the average dose administered was 206 +/- 97 grams. TPN regimens provided 42.0 +/- 8.5 nonprotein kilocalories per kilogram with a nonprotein calorie to nitrogen ratio of 125 to 150:1. The SAC increased from 2.36 +/- 0.38 grams per deciliter to 3.46 +/- 0.26 grams per deciliter immediately after replacement. At follow-up study, the SAC at 6.4 +/- 1.5 days yielded a SAC value of 3.35 +/- 0.30 grams per deciliter, indicating no significant decrease from immediate replacement values. AD can be easily estimated, rapidly replaced and maintained with adequate nutritional support.
使用一个简单公式估算了13名血清白蛋白浓度（SAC）低于3.0克/分升的营养不良患者的白蛋白缺乏量（AD）。在24至72小时的时间段内，将AD作为全胃肠外营养（TPN）配方的一个组成部分进行补充。假设每千克实际体重的分布容积为3分升，最低可接受的SAC为3.5克/分升，据此估算AD。平均AD为200±94克（平均值±标准差），平均给予剂量为206±97克。TPN方案为每千克提供42.0±8.5非蛋白千卡，非蛋白热量与氮的比例为125至150:1。补充后，SAC立即从2.36±0.38克/分升升至3.46±0.26克/分升。在随访研究中，6.4±1.5天时的SAC值为3.35±0.30克/分升，表明与补充后即刻的值相比无显著下降。AD易于估算，通过充足的营养支持可迅速补充并维持。
