Brody J I, Pickering N J, Fink G B
Transfusion. 1986 Sep-Oct;26(5):478-80. doi: 10.1046/j.1537-2995.1986.26587020130.x.
Plasma levels of factor VIII-related antigen (fVIIIRA) and factor XIII S and A subunits (fXIIIS, fXIIIA) were assayed by counterimmunoelectrophoresis before, during, and after cardiopulmonary bypass (CPB) in patients with coronary artery and valvular heart disease to define the basis for clinical and laboratory abnormalities of hemostasis occurring in this form of surgery. During CPB, concentrations of fXIIIA dropped in both patient groups but returned to preoperative levels promptly after pump removal. In contrast, fVIIIRA and fXIIIS, which are not incorporated into the clot, remained unchanged even during fluid administration. These data provide evidence of a transient consumption coagulopathy as a feature of CPB. Hemodilution probably plays a secondary role in these changes.
采用对流免疫电泳法测定了冠状动脉疾病和心脏瓣膜病患者在体外循环（CPB）前、期间及之后血浆中 VIII 因子相关抗原（fVIIIRA）以及 XIII 因子 S 亚基和 A 亚基（fXIIIS、fXIIIA）的水平，以明确这种手术形式中发生的止血临床和实验室异常的基础。在 CPB 期间，两组患者的 fXIIIA 浓度均下降，但在停泵后迅速恢复到术前水平。相比之下，未整合到凝块中的 fVIIIRA 和 fXIIIS 即使在输液期间也保持不变。这些数据证明了短暂性消耗性凝血病是 CPB 的一个特征。血液稀释可能在这些变化中起次要作用。
