Department of Blood Purification, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan,
Blood Purif. 2019;47 Suppl 2:81-87. doi: 10.1159/000496657. Epub 2019 Apr 3.
BACKGROUND/AIMS: Aortic arch calcification (AoAC) is a fatal complication in dialysis. AoAC progression-related molecules in continuous ambulatory peritoneal dialysis (CAPD) remain unclear.
AoAC was estimated using plain chest radiography scoring (AoACS) in 30 CAPD patients (age 49.3 ± 13.4 years). AoAC progression was defined as increased AoACS on follow-up chest X-ray at the end of the study (progressors). Fibroblast growth factor-23 and osteoprotegerin (OPG) were measured.
Median follow-up was 38.5 months. Progressors were older, had shorter PD vintage, higher body mass index, and higher serum OPG levels (255.6 ± 109.2 pg/mL) than nonprogressors (183.4 ± 68.2 pg/mL; p = 0.0400). Progressors also showed higher pulse pressure (62.4 ± 20.0 mm Hg) and pulse wave velocity (1,909.9 ± 310.6 cm/s) than nonprogressors (48.5 ± 13.6 mm Hg; p = 0.0030 and 1,390.1 ± 252.8 cm/s; p = 0.0005, respectively).
AoAC progression was associated with increased aortic stiffness. OPG may be associated with AoAC progression in CAPD.
背景/目的：主动脉弓钙化（AoAC）是透析的致命并发症。持续非卧床腹膜透析（CAPD）中与 AoAC 进展相关的分子尚不清楚。
在 30 名 CAPD 患者（年龄 49.3 ± 13.4 岁）中使用普通胸部 X 线评分（AoACS）评估 AoAC。将随访胸部 X 射线在研究结束时 AoACS 增加定义为 AoAC 进展（进展者）。测量成纤维细胞生长因子 23 和骨保护素（OPG）。
中位随访时间为 38.5 个月。进展者年龄较大，PD 病史较短，体重指数较高，血清 OPG 水平较高（255.6 ± 109.2 pg/mL），而非进展者（183.4 ± 68.2 pg/mL；p = 0.0400）。进展者的脉压（62.4 ± 20.0 mm Hg）和脉搏波速度（1,909.9 ± 310.6 cm/s）也高于非进展者（48.5 ± 13.6 mm Hg；p = 0.0030 和 1,390.1 ± 252.8 cm/s；p = 0.0005）。
AoAC 进展与主动脉僵硬增加有关。OPG 可能与 CAPD 中的 AoAC 进展有关。
