Maeda Institute of Renal Research, Kawasaki, Japan,
Biomarker Society, INC, Kawasaki, Japan,
Blood Purif. 2019;47 Suppl 2:70-73. doi: 10.1159/000496641. Epub 2019 Apr 3.
Optimal iron level in hemodialysis patients remains a subject of debate. The reticulocyte hemoglobin content (CHr) is believed to reflect the concentration of iron required in the most recent hematopoiesis in the bone marrow. CHr is not influenced by any factors that measure direct hemoglobin (Hb) of reticulocytes and is considered a reliable indicator. The supply of iron for Hb synthesis is regulated by hepcidin-25 (Hep-25). However, CHr and Hep-25 measurements are not covered by the Japanese medical insurance system. Serum ferritin (s-ft) and transferrin saturation (TSAT) are used mainly as indicators of internal iron status. Therefore, we examined the relationships among CHr, s-ft, TSAT, and Hep-25 to determine the optimal iron level. This report presents the clinical significance of CHr, the potential use of CHr for the diagnosis of iron deficiency, and tests for optimal iron level using CHr as performed in our hospital.
血液透析患者的最佳铁水平仍是一个争论的话题。网织红细胞血红蛋白含量（CHr）被认为反映了骨髓中最近造血所需的铁浓度。CHr不受任何直接测量网织红细胞血红蛋白（Hb）的因素的影响，被认为是一个可靠的指标。铁用于 Hb 合成的供应受铁调素-25（Hep-25）调节。然而，CHr 和 Hep-25 的测量并不在日本医疗保险系统的覆盖范围内。血清铁蛋白（s-ft）和转铁蛋白饱和度（TSAT）主要用作内部铁状态的指标。因此，我们检查了 CHr、s-ft、TSAT 和 Hep-25 之间的关系，以确定最佳铁水平。本报告介绍了 CHr 的临床意义、CHr 用于诊断缺铁的潜在用途，以及使用 CHr 进行的最佳铁水平检测，这些检测是在我们医院进行的。
