Chen Dan, Qi Wenjing, Xie Suling, Feng Lu, Wang Junying, Wang Lifen, Guan Hongwei
Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.
Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China.
Oncol Lett. 2019 May;17(5):4695-4700. doi: 10.3892/ol.2019.10105. Epub 2019 Mar 4.
Patients with papillary thyroid carcinoma (PTC) usually have multiple tumors, or foci. It remains unclear if these foci originate from independent tumors or a single tumor mass. The present study included 89 female patients with bilateral PTC who had been treated with a total thyroidectomy. An X-chromosome inactivation assay was used to examine the clonal origin of the tumors according to the status of the X-linked human androgen receptor gene. Of the 89 patients, 5 were informative. The X-chromosome inactivation pattern was the same in multiple foci in 3 cases, indicating a monoclonal origin of the tumors. In 1 case, the X chromosome inactivation pattern was different between the tumors. Mixed patterns were observed in 1 case. The results of the present study suggest that in certain cases of multifocal PTC, tumors arise independently, whereas in other cases, separate foci are the outcome of intra-thyroid spread by a single tumor mass.
甲状腺乳头状癌（PTC）患者通常有多个肿瘤或病灶。这些病灶是起源于独立的肿瘤还是单个肿瘤块尚不清楚。本研究纳入了89例行甲状腺全切除术治疗的双侧PTC女性患者。采用X染色体失活分析，根据X连锁人类雄激素受体基因的状态检查肿瘤的克隆起源。89例患者中，5例具有信息价值。3例患者多个病灶的X染色体失活模式相同，表明肿瘤起源于单克隆。1例患者肿瘤之间的X染色体失活模式不同。1例观察到混合模式。本研究结果表明，在某些多灶性PTC病例中，肿瘤独立发生，而在其他病例中，不同病灶是单个肿瘤块甲状腺内播散的结果。
