Klimek L, Casper I, Wollenberg B, Stauber R, Koennecke M
Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
HNO-Universitätsklinik Lübeck, Lübeck, Deutschland.
HNO. 2019 May;67(5):389-400. doi: 10.1007/s00106-019-0649-z.
Release of histamine from mast cells and basophils in inflammatory diseases of the nose and paranasal sinuses has been demonstrated in allergic and non-allergic processes.
A selective literature search was conducted in PubMed and Medline, and publications in German-language journals were additionally analyzed.
The histamine receptors H-H play a role in otorhinolaryngologic inflammatory diseases. To date, the histamine receptor subtype 4 (HR), which is functionally expressed by immune cells in chronic inflammatory diseases, has received little attention. Stimulation of HR influences the release of cytokines and chemokines as well as the migration behavior of immune cells. In animal models blockade of HR reduced inflammation symptoms and pruritus.
HR plays a key role in the pathogenesis of chronic inflammatory diseases and may represent an interesting future therapeutic target.
在变应性和非变应性过程中，已证实在鼻和鼻窦炎性疾病中肥大细胞和嗜碱性粒细胞会释放组胺。
在PubMed和Medline中进行了选择性文献检索，并额外分析了德语期刊上的出版物。
组胺受体H₁-H₄在耳鼻咽喉炎性疾病中发挥作用。迄今为止，组胺受体亚型4（HR₄）在慢性炎性疾病中由免疫细胞功能性表达，但很少受到关注。刺激HR₄会影响细胞因子和趋化因子的释放以及免疫细胞的迁移行为。在动物模型中，阻断HR₄可减轻炎症症状和瘙痒。
HR₄在慢性炎性疾病的发病机制中起关键作用，可能是未来一个有趣的治疗靶点。
