Watanabe K, Nakase H, Kimura Y
Arzneimittelforschung. 1986 Jul;36(7):1022-4.
The effects of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1H)-quinolinone (cilostazol, OPC-13013), acetylsalicylic acid (ASA) and ifenprodil on experimentally induced cerebral infarction were studied in anesthetized rabbits. Cerebral infarction was induced by injecting arachidonic acid (AA) at a dose of 0.5 mg/kg into the unilateral intracarotid artery. After the injection of AA, the brain was perfused with Indian ink, and the degree of thrombus formation was determined by calculating the percentage of perfused area in the hemispheres. The intracarotid injection of AA produced a non-perfused area amounting to 84% of the hemisphere in the injected side and 41% of the hemisphere in the non-injected side. Intravenously administered cilostazol did not produce a definite reduction in carbon-deficient area at 0.1 mg/kg, but it did produce a 49% reduction in the injected side and a 55% reduction in the entire brain at 1 mg/kg. ASA produced a 60% reduction in the carbon-deficient area in the injected side and a 62% reduction in the entire brain at 1 mg/kg. Ifenprodil at 1 mg/kg produced only a 19% reduction in the carbon-deficient area in the injected side.
在麻醉兔身上研究了6-[4-(1-环己基-1H-四氮唑-5-基)丁氧基]-3,4-二氢-2(1H)-喹啉酮（西洛他唑，OPC-13013）、乙酰水杨酸（ASA）和艾芬地尔对实验性诱导脑梗死的影响。通过向单侧颈内动脉注射剂量为0.5mg/kg的花生四烯酸（AA）来诱导脑梗死。注射AA后，用印度墨汁灌注大脑，通过计算半球灌注面积的百分比来确定血栓形成程度。颈内动脉注射AA在注射侧产生了占半球84%的无灌注区域，在未注射侧产生了占半球41%的无灌注区域。静脉注射0.1mg/kg的西洛他唑未使缺碳区域有明显减少，但在1mg/kg时，注射侧减少了49%，全脑减少了55%。1mg/kg的ASA使注射侧缺碳区域减少了60%，全脑减少了62%。1mg/kg的艾芬地尔仅使注射侧缺碳区域减少了19%。
