Prasad Gauri, Giri Anil K, Basu Analabha, Tandon Nikhil, Bharadwaj Dwaipayan
Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110 020, India.
J Genet. 2019 Mar;98.
Elevated C-reactive protein (CRP) serves as an independent biomarker for acute and chronic inflammation, and is also associated with metabolic diseases. Genomewide loci regulating CRP level in Indian population, a high-risk group for metabolic illness, is unexplored. Therefore, we aimed to discover common polymorphisms associated with plasma CRP level in 4493 Indians of Indo-European origin using genomewide association study. Genomewide strong associations of two known intronic variants in hepatocyte nuclear factor-1 α gene () were identified among Indian subjects. We also detected prior associations of several variants in/near metabolic and inflammatory process genes: , , , , and with modest associations. This study confirms that Indians from Indo-European origin display similar core universal genetic factors for CRP levels.
C反应蛋白（CRP）水平升高是急性和慢性炎症的独立生物标志物，还与代谢性疾病相关。在代谢疾病高危人群印度人群中，尚未探索调控CRP水平的全基因组位点。因此，我们旨在通过全基因组关联研究，在4493名印欧血统的印度人中发现与血浆CRP水平相关的常见多态性。在印度受试者中，鉴定出肝细胞核因子-1α基因（）中两个已知内含子变异的全基因组强关联。我们还检测到代谢和炎症过程基因中/附近的几个变异的先前关联：、、、、和具有适度关联。本研究证实，印欧血统的印度人在CRP水平上表现出相似的核心普遍遗传因素。
