Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary; Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Hungary.
Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary; Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Hungary.
J Pharm Biomed Anal. 2019 Jun 5;170:215-219. doi: 10.1016/j.jpba.2019.02.035. Epub 2019 Feb 22.
Adrenaline, noradrenaline, the biogenic catecholamines of vital importance, and four closely related compounds were studied by H NMR-pH titrations, and the resulting acid-base properties are quantified in terms of three macroscopic and twelve microscopic protonation constants for both molecules. The species-specific basicities are interpreted by means of inductive and shielding effects by comparing the protonation constants of the catecholamines, including dopamine. The site-specific basicities determined this way could be key parameters for the interpretation of biochemical behavior.
肾上腺素、去甲肾上腺素、重要的生物源性儿茶酚胺，以及四种密切相关的化合物，通过 1H NMR-pH 滴定进行了研究，并根据两种分子的三个宏观和十二个微观质子化常数对所得的酸碱性质进行了量化。通过比较包括多巴胺在内的儿茶酚胺的质子化常数，利用诱导和屏蔽效应来解释物种特异性碱度。以这种方式确定的特定位置的碱度可能是解释生化行为的关键参数。
