Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Phys Med Biol. 2019 May 16;64(10):105018. doi: 10.1088/1361-6560/ab1614.
The Eplus-260 primate PET is an animal PET imaging system developed by the Institute of High Energy Physics, Chinese Academy of Sciences, which is designed to image non-human primates, especially the brain of large non-human primates. The system consists of 48 block detectors arranged in two 24-sided rings with a ring diameter of 263 mm and an axial extent of 64 mm. Each block detector is composed of a 16 × 16 cerium-doped lutetium-yttrium orthosilicate crystal array with a pixel size of 1.9 × 1.9 × 10 mm. This article presents a performance evaluation of the PET scanner according to the National Electrical Manufacturers Association NU-4 2008 standards. All measurements were made for an energy window of 360-660 keV and a coincidence timing window of 2 ns. In terms of the FWHM, the FBP reconstructed spatial resolution results in all three directions at the radial position of 5 mm were better than or approached to 2 mm, and remained below 3.0 mm within the central 5 cm diameter of the FOV. The peak absolute sensitivity of the scanner was measured 1.80%. For a monkey-sized phantom, the scatter fraction was 34.2% and the peak noise equivalent count rate (NECR) was 26.5 kcps at 64.3 kBq/cc. The overall imaging capabilities of the scanner were also assessed using in vivo imaging study of a rhesus macaque. The performance measurements demonstrate that the Eplus-260 primate PET scanner has the potential ability to obtain good quality and high-contrast images for non-human primates, especially the brain of large non-human primates and could be considered as one technologically advanced dedicated non-human primate PET scanner available today.
Eplus-260 灵长类动物 PET 是由中国科学院高能物理研究所开发的一种动物 PET 成像系统，旨在对非人类灵长类动物进行成像，特别是对大型非人类灵长类动物的大脑进行成像。该系统由 48 个块探测器组成，这些探测器排列在两个 24 边形的环中，环的直径为 263mm，轴向延伸为 64mm。每个块探测器由一个 16 × 16 的掺铈硅酸镥闪烁晶体阵列组成，像素大小为 1.9 × 1.9 × 10mm。本文根据国家电器制造商协会 NU-4 2008 标准，对 PET 扫描仪的性能进行了评估。所有测量均在能量窗口为 360-660keV 和符合时间窗口为 2ns 的情况下进行。在 FWHM 方面，在半径为 5mm 的径向位置，FBP 重建的空间分辨率在所有三个方向上均优于或接近 2mm，在 FOV 的中心 5cm 直径内保持在 3.0mm 以下。扫描仪的峰值绝对灵敏度测量值为 1.80%。对于猴体型的体模，散射分数为 34.2%，在 64.3kBq/cc 时，峰值噪声等效计数率（NECR）为 26.5kcps。还通过对恒河猴的体内成像研究评估了扫描仪的整体成像能力。性能测量表明，Eplus-260 灵长类动物 PET 扫描仪具有为非人类灵长类动物获得高质量、高对比度图像的潜力，特别是对大型非人类灵长类动物的大脑，并且可以被认为是当今可用的一种技术先进的专用非人类灵长类动物 PET 扫描仪。
