长链非编码 RNA 在卵巢癌细胞化疗耐药过程中的调控作用。
The Regulatory Roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer.
机构信息
Department of Biochemistry, China Three Gorges University, Yichang 443002, China.
King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah, 21589, Saudi Arabia.
出版信息
Curr Pharm Des. 2019;25(8):856-861. doi: 10.2174/1381612825666190404122154.
BACKGROUND
Ovarian cancer is the most malignant tumor in gynecological tumors, with low five-year survival rate. The main reasons are diagnosis at advanced stages (the early symptoms are uncharacteristic, and most are diagnosedlate.), relapse, and resistance to existing chemotherapy drugs.
METHODS
Search strategy was performed in the following steps. Firstly, LncRNA related to ovarian cancer was retrieved by using the LncRNA Disease database, and articles were searched by searching keywords: ovarian cancer, drug resistance, and LncRNA retrieved from the LncRNA Disease database.
RESULTS/CONCLUSION: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged, providing a direction for precision medicine of ovarian cancer resistance.
背景
卵巢癌是妇科肿瘤中最恶性的肿瘤，五年生存率低。主要原因是诊断为晚期（早期症状不典型，大多数诊断较晚）、复发和对现有化疗药物的耐药性。
方法
采用以下步骤进行检索策略。首先，通过使用 LncRNA 疾病数据库检索与卵巢癌相关的 LncRNA，然后通过搜索关键词：卵巢癌、耐药性和从 LncRNA 疾病数据库中检索到的 LncRNA，搜索相关文章。
结果/结论：随着卵巢癌耐药性研究的发展，LncRNAs 作为敏感生物标志物和治疗靶点的作用已经显现，为卵巢癌耐药性的精准医学提供了方向。
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