Epel David
Hopkins Marine Station of Stanford University, Pacific Grove, CA, United States.
Methods Cell Biol. 2019;151:3-12. doi: 10.1016/bs.mcb.2019.03.001. Epub 2019 Mar 22.
This memoir/perspective provides some of the back-stories of my half-century fascination with the meeting of sperm and egg. I describe how testing a hypothesis about cell division switched my interests to fertilization and how teaching an undergraduate course resulted in a serendipitous discovery that later led to major insights about sperm-egg recognition. I complete this look at the past with a brief description of the work of a small community of young scientists that provided major insights about the arousal of the egg by the sperm. I end speculating on unappreciated/neglected approaches that might lead to a new way of thinking about the initiation of development at fertilization.
这篇回忆录/观点文章讲述了我对精子与卵子结合长达半个世纪的痴迷背后的一些故事。我描述了对细胞分裂假说的检验如何将我的兴趣转向受精过程，以及教授一门本科课程如何意外地促成了一项发现，该发现后来带来了关于精卵识别的重大见解。我简要介绍了一小群年轻科学家的工作，以此回顾过去，他们的工作为精子激发卵子提供了重要见解。最后，我推测了一些未被重视/忽视的方法，这些方法可能会引发对受精时发育起始的全新思考方式。
