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[艾滋病病原体人类免疫缺陷病毒对昆虫细胞系的感染以及该病毒对非洲原产昆虫的感染证明]

[Infection of insect cell lines by the HIV virus, an agent of AIDS, and a demonstration of insects of African origin infected by this virus].

作者信息

Becker J L, Hazan U, Nugeyre M T, Rey F, Spire B, Barré-Sinoussi F, Georges A, Teulières L, Chermann J C

出版信息

C R Acad Sci III. 1986;303(8):303-6.

PMID:3094848
Abstract

The etiological agent of AIDS known as HIV has been shown to bind on different insect cell lines including Drosophila, Mosquito, Ceratitis; and his DNA to be integrated in the cellular genome, but no expression of the viral genome was detected in those cells. None of the human lymphocytes markers is expressed at the surface of the insect cells. HIV proviral DNA has been also found in various insects from Central Africa (Zaïre and Central Africa Republic) but not similar insects from the Paris area. These data suggest that insects could be a reservoir or a vector for the AIDS virus.

摘要

被称为HIV的艾滋病病原体已被证明能与包括果蝇、蚊子、地中海实蝇在内的不同昆虫细胞系结合;其DNA能整合到细胞基因组中,但在这些细胞中未检测到病毒基因组的表达。昆虫细胞表面未表达任何人类淋巴细胞标志物。在中非(扎伊尔和中非共和国)的各种昆虫中也发现了HIV前病毒DNA,但巴黎地区的类似昆虫中未发现。这些数据表明,昆虫可能是艾滋病病毒的储存库或传播媒介。

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