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Response assessment in acute myeloid leukemia by flow cytometry supersedes cytomorphology at time of aplasia, amends cases without molecular residual disease marker and serves as an independent prognostic marker at time of aplasia and post-induction.

作者信息

Köhnke Thomas, Bücklein Veit, Rechkemmer Sandra, Schneider Stephanie, Rothenberg-Thurley Maja, Metzeler Klaus H, Sauerland Maria-Cristina, Hiddemann Wolfgang, Spiekermann Karsten, Subklewe Marion

机构信息

Laboratory for Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich.

Translational Cancer Immunology, Gene Center, LMU Munich, Munich.

出版信息

Haematologica. 2019 Nov;104(11):e510-e513. doi: 10.3324/haematol.2018.215236. Epub 2019 Apr 4.

DOI:10.3324/haematol.2018.215236
PMID:30948486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6821611/
Abstract
摘要

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Leukemia. 2018 Dec;32(12):2558-2571. doi: 10.1038/s41375-018-0268-9. Epub 2018 Oct 1.
2
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.急性髓系白血病的分子微小残留病。
N Engl J Med. 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863.
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Flow cytometric demonstration of decrease in bone marrow leukemic blasts after 'Day 14' without further therapy in acute myeloid leukemia.急性髓系白血病患者在“第14天”后未经进一步治疗，流式细胞术显示骨髓白血病原始细胞减少。
Leuk Lymphoma. 2017 Nov;58(11):2717-2719. doi: 10.1080/10428194.2017.1307359. Epub 2017 Mar 28.
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Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel.成人急性髓系白血病的诊断与管理：2017年国际专家小组的欧洲白血病网络（ELN）建议
Blood. 2017 Jan 26;129(4):424-447. doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28.
5
Effect of genetic profiling on prediction of therapeutic resistance and survival in adult acute myeloid leukemia.基因谱分析对成人急性髓系白血病治疗耐药性预测及生存的影响。
Leukemia. 2015 Oct;29(10):2104-7. doi: 10.1038/leu.2015.76. Epub 2015 Mar 16.
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