Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin, 150040, P. R. China.
Org Biomol Chem. 2019 Apr 17;17(16):4014-4023. doi: 10.1039/c9ob00482c.
An efficient palladium-catalyzed route for tandem synthesis of imidazole-fused polyheterocycles from 2-vinyl imidazoles and aryl halides is described. The sequentially accomplished process comprises intermolecular Heck arylation of 2-vinyl imidazoles followed by an intramolecular aerobic oxidative C-H amination reaction promoted by the same Pd catalyst. This Pd-catalyzed tandem approach offers a straightforward protocol for the assembly of benzimidazo/phenanthroimidazo[1,2-a]quinolines in moderate to high yields, serving as a useful tool for the discovery of fluorescent materials.
本文描述了一种从 2-乙烯基咪唑和芳基卤化物出发，经钯催化串联合成咪唑稠合多杂环的有效方法。该串联过程依次包括 2-乙烯基咪唑的分子间 Heck 芳基化反应，以及在相同的钯催化剂作用下，通过分子内有氧氧化 C-H 胺化反应。该钯催化的串联方法为苯并咪唑/菲并咪唑[1,2-a]喹啉的构建提供了一种直接的方法，在中等至较高产率下得到目标产物，可作为发现荧光材料的有用工具。
