Pediatric Neurology, Department of Neurology, University of Virginia, Charlottesville, VA, USA.
College of Arts and Sciences, University of Virginia, Charlottesville, VA, USA.
Dev Med Child Neurol. 2019 Nov;61(11):1289-1294. doi: 10.1111/dmcn.14233. Epub 2019 Apr 5.
To characterize growth trajectories of children who develop multiple sclerosis compared to typically developing, regional peers and Centers for Disease Control (CDC) normative values.
This case-control study collected weight, height, and body mass index (BMI) in 40 consecutive pediatric patients with multiple sclerosis (28 females, 12 males), in addition to 120 typically developing peers (84 females, 36 males), identified and matched for year of birth, sex, ethnicity, and socio-economic status. BMI values were converted to z-scores based on CDC reference values and were compared with respect to age between our two cohorts and by years relative to multiple sclerosis onset for cases.
Median age for the clinical onset of multiple sclerosis was 15 years. BMI z-scores are significantly higher for patients with multiple sclerosis compared to typically developing, demographically-matched peers and CDC standards. These significant differences in BMI are noted from 4 years of age and onward. Height trajectories were similar among case and control individuals and CDC normative values.
BMI in pediatric multiple sclerosis is markedly higher, beginning in early childhood, years before the clinical-onset of the disease.
Children with multiple sclerosis are significantly more overweight than typically developing peers at the time of diagnosis. Body mass index trajectories are significantly higher years before the clinical manifestation(s) of multiple sclerosis.
与正常发育的同龄儿童和疾病控制与预防中心（CDC）的标准值相比，描绘多发性硬化症患儿的生长轨迹。
本病例对照研究共纳入了 40 名连续的多发性硬化症患儿（28 名女性，12 名男性），除了 120 名正常发育的同龄儿童（84 名女性，36 名男性），所有患儿均按出生年份、性别、种族和社会经济地位进行了识别和匹配。根据 CDC 的参考值，将 BMI 值转换为 z 分数，并比较了我们两个队列之间的年龄以及病例相对于多发性硬化症发病的年限。
多发性硬化症的临床发病中位年龄为 15 岁。与正常发育、人口统计学匹配的同龄儿童和 CDC 标准相比，多发性硬化症患儿的 BMI z 分数明显更高。从 4 岁开始，这种 BMI 的显著差异就可以观察到。病例和对照组个体以及 CDC 标准值的身高轨迹相似。
在多发性硬化症儿童中，BMI 明显较高，早在疾病的临床发病前几年就开始了。
在多发性硬化症患儿诊断时，他们的超重比例明显高于正常发育的同龄人。在多发性硬化症的临床表现出现多年前，体重指数的轨迹就已经显著升高。
