Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou, 225300, Jiangsu Province, China.
Yangtze River Pharmaceutical Group, Taizhou, 225321, Jiangsu Province, China.
Fundam Clin Pharmacol. 2019 Dec;33(6):621-633. doi: 10.1111/fcp.12466. Epub 2019 Apr 24.
Felbamate is an anticonvulsant used in the treatment of epilepsy. In this study, we investigated the antidepressant-like actions of felbamate in mice. The effects of felbamate were first assessed using the forced swimming test (FST) and tail suspension test (TST), and then investigated in the chronic unpredictable mild stress (CUMS) and chronic social defeat stress (CSDS) models of depression. The changes in the hippocampal brain-derived neurotrophic factor (BDNF) signaling cascade after chronic stress and felbamate treatment were also examined. It was found that felbamate exhibited antidepressant-like activities in the FST and TST without affecting the locomotor activity of mice. Felbamate was also effective in both the CUMS and CSDS models of depression. Moreover, felbamate administration fully restored the decreased hippocampal BDNF signaling pathway in both the CUMS-stressed and CSDS-stressed mice. Collectively, felbamate has antidepressant-like actions in mice involving the hippocampal BDNF system.
苯妥英是一种用于治疗癫痫的抗惊厥药物。在这项研究中，我们研究了苯妥英在小鼠中的抗抑郁作用。首先使用强迫游泳试验（FST）和悬尾试验（TST）评估苯妥英的作用，然后在慢性不可预测轻度应激（CUMS）和慢性社会挫败应激（CSDS）抑郁模型中进行研究。还检查了慢性应激和苯妥英治疗后海马脑源性神经营养因子（BDNF）信号级联的变化。结果发现，苯妥英在 FST 和 TST 中表现出抗抑郁样活性，而不影响小鼠的运动活性。苯妥英在 CUMS 和 CSDS 抑郁模型中也有效。此外，苯妥英给药完全恢复了 CUMS 应激和 CSDS 应激小鼠海马 BDNF 信号通路的降低。总之，苯妥英在小鼠中具有抗抑郁样作用，涉及海马 BDNF 系统。
