Faculty of Veterinary and Animal Sciences, University of Chile, Santa Rosa 11735, La Pintana, Santiago, 8820808, Chile.
Membrane Biochemistry Laboratory, Department of Physiology and Biophysics, Faculty of Medicine, University of Chile, Independencia 1027, Santiago, 8389100, Chile.
Toxicon. 2019 Jun;164:26-30. doi: 10.1016/j.toxicon.2019.03.021. Epub 2019 Apr 3.
To evaluate Neosaxitoxin (NeoSTX) as a local anesthetic drug, for pain control during and after piglet castration.
Prospective, randomized and double-blind study.
24 commercial hybrids, males, 23-day-old piglets.
The piglets were randomized into two groups: a Lidocaine group and a NeoSTX group. One minute before castration, they were injected intra-scrotally with a single dose of Lidocaine (20 mg, in 1 mL) and NeoSTX (0.1 μg, in 1 mL), respectively.
NeoSTX does not generate vasoconstriction or scrotal contraction, unlike Lidocaine, where a decrease in temperature and scrotal size is observed within 5 min after the procedure. After 24 h, wound inflammation, as measured by scrotal size, was lower in the NeoSTX group. No significant difference could be shown between the vocalizations and facial expressions of pain of both groups during the castration procedure.
A single dose of NeoSTX is safe and effective for pain management during and after piglet castration. NeoSTX treated piglets were less affected by castration than those in the Lidocaine group, thus reducing piglet stress and enhancing the quality of piglet convalescence.
评估 neo 石房蛤毒素（NeoSTX）作为一种局部麻醉药物，用于控制仔猪去势过程中和去势后的疼痛。
前瞻性、随机和双盲研究。
24 只商业杂交雄性 23 日龄仔猪。
将仔猪随机分为两组：利多卡因组和 NeoSTX 组。在去势前 1 分钟，分别向其鞘内注射单剂量利多卡因（20mg，1ml）和 NeoSTX（0.1μg，1ml）。
与利多卡因不同，NeoSTX 不会引起血管收缩或阴囊收缩，在手术后 5 分钟内可观察到温度和阴囊大小下降。在 24 小时后，NeoSTX 组的阴囊肿胀炎症（通过阴囊大小测量）低于利多卡因组。在去势过程中，两组仔猪的发声和面部表情疼痛均无明显差异。
单次剂量的 NeoSTX 可安全有效地用于仔猪去势过程中和去势后的疼痛管理。NeoSTX 处理的仔猪比利多卡因组仔猪受去势的影响更小，从而减轻仔猪应激，提高仔猪康复质量。
