Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Semin Cancer Biol. 2019 Dec;59:112-124. doi: 10.1016/j.semcancer.2019.04.001. Epub 2019 Apr 2.
Epigenetic alterations, along with genetic alterations, have long been regarded as the most important mechanism participating in carcinogenesis. DNA methylation, histone modifications, and RNA-mediated regulation are involved in many cellular processes that are essential to cancer initiation and progression. A plethora of chromatin-associated proteins and modifying proteins take control of these processes and they are under the modulation of signaling pathways. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway (PI3K/AKT) is in manage of multiple biological processes and is frequently aberrantly activated in human cancers. Increasing evidence has demonstrated that critical epigenetic modifiers are directly or indirectly modulated by PI3K/AKT signaling, and participate in oncogenicity of PI3K cascade in cancers. In this review, we revisit the mechanism of the PI3K/AKT signaling pathway modulating epigenetic reprogramming in cancer and attempt to establish the connection between PI3K/AKT cascade and the epigenome.
表观遗传改变与遗传改变一样，长期以来一直被认为是参与癌症发生的最重要机制。DNA 甲基化、组蛋白修饰和 RNA 介导的调节参与了许多对癌症发生和进展至关重要的细胞过程。大量与染色质相关的蛋白质和修饰蛋白质控制着这些过程，它们受信号通路的调节。磷脂酰肌醇 3-激酶 (PI3K)/AKT 途径 (PI3K/AKT) 负责多种生物过程，在人类癌症中经常异常激活。越来越多的证据表明，关键的表观遗传修饰剂直接或间接地受到 PI3K/AKT 信号的调节，并参与癌症中 PI3K 级联的致癌性。在这篇综述中，我们重新审视了 PI3K/AKT 信号通路调节癌症中表观遗传重编程的机制，并试图在 PI3K 级联和表观基因组之间建立联系。
