胸腺癌和胸内神经内分泌肿瘤患者的临床病理特征对生存的影响：基于人群的分析。

Effect of clinicopathologic features on survival of patients with thymic carcinomas and thymic neuroendocrine tumors: A population-based analysis.

机构信息

Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

出版信息

Curr Probl Cancer. 2019 Oct;43(5):411-420. doi: 10.1016/j.currproblcancer.2019.03.004. Epub 2019 Mar 29.

DOI:10.1016/j.currproblcancer.2019.03.004

PMID:30952367

Abstract

BACKGROUND

Thymic carcinomas (TCs) and thymic neuroendocrine tumors (TNETs) are aggressive cancers with poor survival outcome and limited investigation. This study is to investigate clinicopathologic features on TC and TNET patients' prognosis of a large cohort.

MATERIALS AND METHODS

The Surveillance, Epidemiology, and End Results database were used to identify a total of 362 TC and TNET patients with documented clinicopathologic features we investigated. The characteristics and overall survival of the TC and TNET patients were studied.

RESULTS

Two hundred and forty TC and 122 TNET patients were identified. For the entire cohort of TC and TNET, histologic type (P < 0.001), tumor size (P = 0.015), Masaoka-Koga stage (P = 0.008), regional node positive (P = 0.004), surgery of primary site (P < 0.001), lymph node surgery (P = 0.013), and chemotherapy (P = 0.001) were considered as significant clinicopathologic features that could affect prognosis of TC and TNET patients in univariate analysis. More importantly, histologic type (P < 0.001), regional nodes positive (P = 0.03) and surgery of primary site (P < 0.001) were able to independently predict overall survival of those patients. In addition, for the cohort of TC, we found that regional nodes positive (P = 0.034) and surgery of primary site (P = 0.001) could be independent predictors of TC patients' survival.

CONCLUSION

Regional nodes detection is essential for TC and TNET patients. Surgery of primary site is the preferred primary treatment for those patients.

摘要

背景

胸腺癌（TC）和胸神经内分泌肿瘤（TNET）是侵袭性癌症，生存预后差，研究有限。本研究旨在调查大样本 TC 和 TNET 患者的临床病理特征及其对预后的影响。

材料与方法

利用监测、流行病学和最终结果数据库，共确定了 362 例 TC 和 TNET 患者，记录了我们所研究的临床病理特征。研究了 TC 和 TNET 患者的特征和总生存率。

结果

共确定了 240 例 TC 和 122 例 TNET 患者。对于 TC 和 TNET 的整个队列，组织学类型（P < 0.001）、肿瘤大小（P = 0.015）、Masaoka-Koga 分期（P = 0.008）、区域淋巴结阳性（P = 0.004）、原发部位手术（P < 0.001）、淋巴结手术（P = 0.013）和化疗（P = 0.001）被认为是影响 TC 和 TNET 患者预后的重要临床病理特征。更重要的是，组织学类型（P < 0.001）、区域淋巴结阳性（P = 0.03）和原发部位手术（P < 0.001）能够独立预测这些患者的总生存率。此外，对于 TC 队列，我们发现区域淋巴结阳性（P = 0.034）和原发部位手术（P = 0.001）是 TC 患者生存的独立预测因素。