新型自分泌 CXCL14/ACKR2 轴：癌症转移的阿喀琉斯之踵？
A Novel Autocrine CXCL14/ACKR2 Axis: The Achilles' Heel of Cancer Metastasis?
机构信息
Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, and State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P.R. China.
Department of Biomedical Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong, P.R. China.
出版信息
Clin Cancer Res. 2019 Jun 15;25(12):3476-3478. doi: 10.1158/1078-0432.CCR-19-0853. Epub 2019 Apr 5.
Cancer-associated fibroblasts (CAF) are essential for cancer hallmarks. While CAFs are molecularly heterogeneous, a CXCL14-expressing subset has been a critical player in the cancer context. In breast cancer, an autocrine fibroblast CXCL14/ACKR2 axis mediates epithelial-to-mesenchymal transition and endows metastatic traits, which offers novel therapeutic potential in the clinical setting..
癌症相关成纤维细胞 (CAF) 是癌症特征的关键。虽然 CAF 在分子上具有异质性，但表达 CXCL14 的亚群在癌症环境中一直是关键参与者。在乳腺癌中，自分泌成纤维细胞 CXCL14/ACKR2 轴介导上皮间质转化并赋予转移特性，这为临床提供了新的治疗潜力。
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