Hu Dingyuan, Ansari Daniel, Bauden Monika, Zhou Qimin, Andersson Roland
Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, P.R. China.
Department of Clinical Sciences Lund, Surgery, Faculty of Medicine, Lund University, Lund, Sweden.
Anticancer Res. 2019 Apr;39(4):1661-1666. doi: 10.21873/anticanres.13271.
Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasis and immune modulation. Emerging evidence suggests that CLCA1 may also be involved in the pathophysiology of colorectal, pancreatic and ovarian cancer. There is growing interest in utilizing CLCA1 as a diagnostic, prognostic and predictive biomarker, as well as a potential therapeutic target. In this review, the functional role of CLCA1, with a particular focus on cancer, is described.
钙激活氯离子通道调节因子1（CLCA1）属于一组分泌型自切割蛋白，可激活钙依赖性氯离子通道。CLCA1已被证明参与哮喘等炎症性气道疾病的发病机制。最近，CLCA1的其他功能也已被揭示，包括其金属蛋白酶特性以及在黏液稳态和免疫调节中的作用。新出现的证据表明，CLCA1也可能参与结直肠癌、胰腺癌和卵巢癌的病理生理学过程。人们越来越有兴趣将CLCA1用作诊断、预后和预测生物标志物以及潜在的治疗靶点。在这篇综述中，将描述CLCA1的功能作用，尤其关注其在癌症中的作用。
