Kubota Yoshiki, Ohno Tatsuya, Kawashima Motohiro, Murata Kazutoshi, Okonogi Noriyuki, Noda Shin-Ei, Tsuda Kazuhisa, Sakai Makoto, Tashiro Mutsumi, Nakano Takashi
Gunma University Heavy Ion Medical Center, Maebashi, Japan
Gunma University Heavy Ion Medical Center, Maebashi, Japan.
Anticancer Res. 2019 Apr;39(4):1915-1921. doi: 10.21873/anticanres.13300.
We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer.
Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose-volume parameters (V, V, V, and D) of the rectum, sigmoidal colon, and bladder were evaluated.
The mean±standard deviation of the rectal volume in CIRT for V with and without the device were 2.1±2.1 and 13.6±4.4 ml, respectively, and those in IMRT were 2.0±2.2 and 13.7±3.8 ml, respectively; these values were significantly lower in CIRT and IMRT using this device.
Using our novel vaginal immobilization device, high rectal doses were largely reduced in CIRT and IMRT.
我们开发了一种用于妇科恶性肿瘤体外放疗的阴道固定装置，并评估了其在宫颈癌患者碳离子放疗（CIRT）和调强放射治疗（IMRT）期间对肠道的剂量降低效果。
对7例宫颈癌患者在使用和不使用该装置的情况下获得的计算机断层扫描图像进行评估。生成了CIRT和IMRT的治疗计划，并评估了直肠、乙状结肠和膀胱的剂量体积参数（V、V、V和D）。
在CIRT中，使用和不使用该装置时V的直肠体积平均值±标准差分别为2.1±2.1和13.6±4.4 ml，在IMRT中分别为2.0±2.2和13.7±3.8 ml；在使用该装置的CIRT和IMRT中，这些值显著更低。
使用我们新型的阴道固定装置，在CIRT和IMRT中直肠高剂量大幅降低。
