Section of Transplantation, Department of Surgery, The University of Chicago, Chicago, IL, USA.
Nat Biomed Eng. 2019 Apr;3(4):251-252. doi: 10.1038/s41551-019-0389-0.
Nanoparticle sensors of the activity of the protease granzyme B detect early T-cell-mediated rejection of transplanted skin grafts in mice via the release of a proteolytically cleaved fluorescence reporter that filters into urine.
纳米颗粒传感器可以检测组织蛋白酶 B 的活性，通过检测滤入尿液的被蛋白水解切割的荧光报告分子来检测移植皮肤中早期 T 细胞介导的排斥反应。
