基于激光解吸飞行时间质谱检测血晶素对疟疾筛查的灵敏度不足。
Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening.
机构信息
Department of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany; Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany.
出版信息
J Microbiol Methods. 2019 May;160:104-106. doi: 10.1016/j.mimet.2019.04.002. Epub 2019 Apr 3.
Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.
基于激光解吸飞行时间（LD-TOF）质谱的血晶检测作为疟疾的快速筛选试验，其性能特征得到了评估。尽管特异性>95%，但对显微镜阳性样本的敏感性仅为 80.2%，这使得这种易于应用和快速的方法不适合常规诊断环境。
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