School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Drug Discov Today. 2019 Aug;24(8):1654-1659. doi: 10.1016/j.drudis.2019.03.027. Epub 2019 Apr 3.
The suprachoroidal space (SCS), a potential anatomical space between the sclera and choroid, is a novel route for drug delivery targeting the chorioretinal layers of the eye. The safety and efficacy of SCS drug delivery have been shown in multiple clinical trials. Recent studies have developed methods for more precise targeting within the SCS at sites of action at the posterior pole (e.g., macula), near the limbus (e.g., ciliary body), and throughout the SCS using iontophoresis, swollen hydrogels, high-density particle emulsions, highly viscous and non-Newtonian fluids, and microstents. Here, we review novel technologies targeting the posterior, anterior, or entire SCS.
脉络膜上腔（SCS）是巩膜和脉络膜之间的潜在解剖空间，是一种靶向眼部脉络膜视网膜层的新型药物输送途径。SCS 药物输送的安全性和有效性已在多项临床试验中得到证实。最近的研究已经开发出了在后部（例如黄斑）、周边（例如睫状体）以及整个 SCS 内更精确靶向作用部位的方法，使用离子电渗、肿胀水凝胶、高密度颗粒乳液、高粘度和非牛顿流体以及微支架。在这里，我们综述了靶向后部、前部或整个 SCS 的新技术。
