Warsaw University of Technology, Faculty of Chemical and Process Engineering, Department of Biotechnology and Bioprocess Engineering, Waryńskiego 1, 00-645 Warsaw, Poland.
Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, Poleczki 19, 02-822 Warsaw, Poland.
Colloids Surf B Biointerfaces. 2019 Jul 1;179:136-142. doi: 10.1016/j.colsurfb.2019.03.069. Epub 2019 Apr 1.
The aim of this work was to elaborate the 3D printed polylactide (PLA) polymeric scaffolds and, subsequently, study the possibility of coating thereof with a biomedical polyvinylpyrrolidone (PVP) hydrogel through the previously patented protocol. Such materials have a potential to be applied in biomedical engineering, e.g. for tissue regeneration. PVP layer according to the present paper could constitute a useful biocompatible supporting layer for drug delivering implant surfaces of any shape. Polylactide (PLA) both in forms of flat foils and 3D-printed scaffolds was used to be coated with PVP layer with the Fenton-type reaction that enables the polymeric scaffold grafting with hydrogel in two easy steps. The study revealed that PVP was successfully grafted to PLA substrates. Most optimal parameters for PVP grafting process were selected. The PLA-PVP materials were found to be hydrophilic and non-toxic which is promising considering their biomedical application. The method comprising well-tested PLA scaffolds printing and then grafting them with PVP layer has a promising potential to be brought in to the industrial production due to its simplicity.
本工作旨在通过先前获得专利的方案，详细说明 3D 打印的聚乳酸（PLA）聚合物支架，随后研究用生物医学聚乙烯吡咯烷酮（PVP）水凝胶对其进行涂层的可能性。这些材料具有在生物医学工程中的应用潜力，例如用于组织再生。根据本文，PVP 层可构成用于任何形状的药物输送植入物表面的有用的生物相容的支撑层。聚乳酸（PLA）无论是在薄片还是 3D 打印支架的形式下，都可以通过芬顿型反应来涂覆 PVP 层，该反应可使聚合物支架在两步轻松的步骤中与水凝胶接枝。研究表明，PVP 成功地接枝到 PLA 基质上。选择了最适合 PVP 接枝过程的最佳参数。发现 PLA-PVP 材料具有亲水性和非毒性，考虑到它们的生物医学应用，这是很有前途的。由于其简单性，包括经过充分测试的 PLA 支架打印，然后用 PVP 层接枝的方法具有在工业生产中引入的广阔潜力。
