新生儿脑血流动力学的实验研究

Experimental study on the hemodynamics of the neonatal brain.

作者信息

Hidaka A, Suzuki Y, Komatani M, Ikeda H, Kitanaka T, Sugawa T

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1986 Sep;38(9):1633-8.

Abstract

The effects of inhalation of different gases were studied in neonatal rabbits with the following results: In neonates with normal heart rate (HR), hyperoxia induced by O2 inhalation did not appreciably affect HR, but it increased cerebral tissue PO2, while decreasing cerebral blood flow (CBF). In many of those which fell into a state of marked bradycardia, not only HR and CBF but also cerebral tissue PO2 levels were recovered as a result of O2 inhalation. CBF was increased even when HR was hardly changed (at least when the HR decrease was 10% or less) by hypercarbia due to inhalation of CO2 mixed air. Severe hyperoxia induced by N2O inhalation caused bradycardia and reduced CBF.

摘要

在新生兔中研究了吸入不同气体的影响，结果如下：在心率（HR）正常的新生儿中，吸入氧气引起的高氧血症对心率没有明显影响，但会增加脑组织的氧分压（PO2），同时减少脑血流量（CBF）。在许多出现明显心动过缓状态的新生兔中，吸入氧气后不仅心率和脑血流量，而且脑组织的氧分压水平都得到了恢复。由于吸入二氧化碳混合空气导致高碳酸血症，即使心率几乎没有变化（至少心率下降10%或更低）时，脑血流量也会增加。吸入氧化亚氮引起的严重高氧血症会导致心动过缓和脑血流量减少。