在溶液和固态状态下对帕地马汀 O 与环糊精受体之间非共价相互作用的物理化学研究。

Physicochemical investigations on non-covalent interactions between Padimate O and cyclodextrin receptors in both solution and solid states.

机构信息

Department of Chemistry, University of North Bengal, Darjeeling 734013, India.

出版信息

Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jul 5;218:9-14. doi: 10.1016/j.saa.2019.03.058. Epub 2019 Mar 19.

DOI:10.1016/j.saa.2019.03.058

Abstract

Ultraviolet B (UV-B) radiation is very harmful to human body. It can cause serious health problem mainly skin cancer, sunburn and photo-aging. Padimate O (PMO) is a sunscreen agent. The aim of this work is to form inclusion complexes with α-cyd and β-cyd in both aqueous environment and solid state that established by UV-Vis, FTIR spectroscopy, mass spectra, powder X-ray diffraction pattern and as α-cyd and β-cyd are known to us as good drug vehicles, hence, the experimental results suggest that they can be used as good sunscreen agent carrier and photostabilizer additive for increasing the photostability and other properties of PMO. In solution phase, UV-Vis spectroscopy demonstrated that the entire process of formation of complexes is observed with 1:1 stoichiometry which is further justified by mass spectra. Thermodynamic parameters support the whole process in both cases and it is revealed that β-cyd forms more firmly inclusion complex than α-cyd with PMO. Successful formation of solid inclusion complexes is supported by FTIR spectroscopy and powder-XRD. The enhancement of the thermal stability of the α-cyd/PMO and β-cyd/PMO complexes is demonstrated by TGA study.

摘要

紫外线 B（UV-B）辐射对人体非常有害。它会导致严重的健康问题，主要是皮肤癌、晒伤和光老化。对氨基苯甲酸辛酯（PMO）是一种防晒霜。这项工作的目的是在水相和固态环境中与 α-环糊精和 β-环糊精形成包合物，通过紫外可见光谱、傅里叶变换红外光谱、质谱、粉末 X 射线衍射图和证明，由于 α-环糊精和 β-环糊精被我们认为是良好的药物载体，因此，实验结果表明它们可以用作良好的防晒霜载体和光稳定剂添加剂，以提高 PMO 的光稳定性和其他性能。在溶液相中，紫外可见光谱表明，复合物的形成过程是通过 1:1 的化学计量比来观察的，这进一步通过质谱得到了证实。热力学参数支持这两种情况下的整个过程，结果表明β-环糊精与 PMO 形成的包合物比 α-环糊精更牢固。傅里叶变换红外光谱和粉末 X 射线衍射图支持固体包合物的成功形成。通过 TGA 研究证明了 α-环糊精/PMO 和 β-环糊精/PMO 复合物热稳定性的提高。