Wang J, Liu L T, Cui D, He L, Liu D G
Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.
Zhonghua Bing Li Xue Za Zhi. 2019 Apr 8;48(4):288-292. doi: 10.3760/cma.j.issn.0529-5807.2019.04.005.
To investigate the prevalence of BRAF V600E mutation in thyroid nodules and to analyze the relationship between BRAF V600E mutation and various clinicopathological features. BRAF V600E mutant gene test was done in 463 cases of thyroid nodules collected from April 2015 to July 2018 in Beijing Hospital. Pathologic sections of 444 cases of papillary thyroid carcinoma were reviewed and clinical information was collected.Statistical analysis of the relationship between BRAF V600E gene mutation and various clinicopathological features was performed with SPSS 21.0 statistical software. There were 109 males and 354 females in the cohort, with a male to female ratio of 1.0∶3.2. The patient ranged in age from 16 to 82 years, with an average age of 46.1 years. The BRAF V600E mutation rates in papillary thyroid carcinoma, benign thyroid nodules and other thyroid carcinoma were 86.5%(384/444),0/15 and 1/4,respectively.There was significant correlation between BRAF V600E mutation and histological diagnosis of papillary thyroid carcinoma (0.05). There was no correlation with age, gender, multifocality, bilaterality, coexisting lymphocytic thyroiditis, nodular goiter, maximum diameter, capsule invasion, extrathyroidal extension and clinical stage (0.05). BRAF V600E gene mutation is closely related to the occurrence of papillary thyroid carcinoma. BRAF V600E has significant value in the diagnosis of papillary thyroid carcinoma. While BRAF V600E mutation is related to the histological diagnosis, it shows no correlation with other clinicopathologic features. BRAF V600E mutation is not an independent prognostic factor in papillary thyroid carcinoma patients.
探讨甲状腺结节中BRAF V600E突变的发生率，并分析BRAF V600E突变与各种临床病理特征之间的关系。对2015年4月至2018年7月在北京医院收集的463例甲状腺结节进行BRAF V600E突变基因检测。回顾444例甲状腺乳头状癌的病理切片并收集临床资料。采用SPSS 21.0统计软件对BRAF V600E基因突变与各种临床病理特征之间的关系进行统计分析。该队列中有男性109例，女性354例，男女比例为1.0∶3.2。患者年龄范围为16至82岁，平均年龄为46.1岁。甲状腺乳头状癌、良性甲状腺结节和其他甲状腺癌中BRAF V600E突变率分别为86.5%（384/444）、0/15和1/4。BRAF V600E突变与甲状腺乳头状癌的组织学诊断之间存在显著相关性（P<0.05）。与年龄、性别、多灶性、双侧性、并存淋巴细胞性甲状腺炎、结节性甲状腺肿、最大直径、包膜侵犯、甲状腺外侵犯及临床分期均无相关性（P>0.05）。BRAF V600E基因突变与甲状腺乳头状癌的发生密切相关。BRAF V600E在甲状腺乳头状癌的诊断中具有重要价值。虽然BRAF V600E突变与组织学诊断相关，但与其他临床病理特征无相关性。BRAF V600E突变不是甲状腺乳头状癌患者的独立预后因素。
