Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium; Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK.
Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.
Trends Immunol. 2019 May;40(5):431-446. doi: 10.1016/j.it.2019.03.001. Epub 2019 Apr 5.
ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for their role in driving epithelial to mesenchymal transition. However, in recent years our understanding of these two transcription factors has broadened, and it is now clear that they are expressed by a variety of immune cells of both myeloid and lymphoid lineages, including dendritic cells, macrophages, monocytes, B, T, and NK cells. In these cells, ZEBs function to regulate important transcriptional networks necessary for cell differentiation, maintenance, and function. Here, we review the current understanding of ZEB regulation across immune cell lineages, particularly in mice, highlighting present gaps in our knowledge. We also speculate on important questions for the future.
ZEB1 和 ZEB2 是锌指 E 盒结合转录因子，以其在驱动上皮细胞向间充质转化中的作用而闻名。然而，近年来，我们对这两种转录因子的理解已经拓宽，现在很清楚，它们由各种髓系和淋巴系免疫细胞表达，包括树突状细胞、巨噬细胞、单核细胞、B、T 和 NK 细胞。在这些细胞中，ZEB 调节细胞分化、维持和功能所必需的重要转录网络。在这里，我们综述了目前对免疫细胞谱系中 ZEB 调节的理解，特别是在小鼠中的理解，突出了我们知识中的现有差距。我们还对未来的重要问题进行了推测。
