丙型肝炎中，miR-29b和Claudin的基线肝水平分别与纤维化阶段和HCV RNA相关。

Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C.

作者信息

Sendi Hossein, Mehrab-Mohseni Marjan, Russo Mark W, Steuerwald Nury, Jacobs Carl, Clemens Mark G, Bonkovsky Herbert L

机构信息

The Liver-Biliary-Pancreatic Center, Carolinas Medical Center, Charlotte, NC, USA.

Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA.

出版信息

Clin Exp Gastroenterol Hepatol. 2019 Jan-May;1(1). Epub 2019 Mar 8.

PMID:30957098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6448799/

Abstract

We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). A total of 25 CHC patients (genotype 1) who were treatment naive at the time of sample collection enrolled in this study. By multivariate analysis, CLDN RNA was found as the single independent factor positively correlated with HCV RNA levels (p=0.003), while hepatic miR-29b levels was found as the single independent factor for predicting advanced stage of fibrosis (p=0.028). Conclusion: Our results highlight miR-29b and CLDN as novel predictors of advanced stage of liver fibrosis and baseline HCV RNA in CHC.

摘要

我们试图确定慢性丙型肝炎（CHC）患者中，miR-122、miR-29b、紧密连接蛋白（Claudin）、闭合蛋白（Occludin）、蛋白激酶R（PKR）或PKR激活剂（PRKRA）的基线肝脏水平是否与HCV RNA或纤维化阶段相关。本研究共纳入了25例在样本采集时未接受过治疗的CHC患者（基因1型）。通过多变量分析，发现紧密连接蛋白RNA是与HCV RNA水平呈正相关的单一独立因素（p=0.003），而肝脏miR-29b水平是预测纤维化晚期的单一独立因素（p=0.028）。结论：我们的结果突出了miR-29b和紧密连接蛋白作为CHC中肝纤维化晚期和基线HCV RNA的新型预测指标。