[使用体外药代动力学模拟模型研究头孢匹胺对铜绿假单胞菌的杀菌活性]
[Bactericidal activity of cefpiramide on P. aeruginosa using an in vitro pharmacokinetic simulation model].
作者信息
Drigues P, Labrousse M, Combes T, Mas C, Roche G
出版信息
Pathol Biol (Paris). 1986 May;34(5):431-5.
Cefpiramide (CPM) is a new cephalosporin with good activity against Pseudomonas. Sustained high serum concentrations are observed. We studied CPM killing kinetics using an in vitro model that simulates the pharmacokinetic profile observed in humans following a single intramuscular injection. The strain tested was Pseudomonas aeruginosa NCTC 8203. CPM was compared to cefoperazone (CPZ), cefsulodin (CFS) and ceftazidime (CTZ). These drugs differed only for the time-interval to bacterial regrowth that was in the following ascending order: CFS, CPZ, CTZ and CPM. This finding corroborates the fact that cefpiramide's pharmacokinetic properties allow wider space intervals between doses than for other drugs.
头孢匹胺（CPM）是一种对假单胞菌有良好活性的新型头孢菌素。可观察到血清浓度持续处于高位。我们使用一种体外模型研究了头孢匹胺的杀菌动力学，该模型模拟单次肌内注射后在人体中观察到的药代动力学特征。所测试的菌株为铜绿假单胞菌NCTC 8203。将头孢匹胺与头孢哌酮（CPZ）、头孢磺啶（CFS）和头孢他啶（CTZ）进行了比较。这些药物的区别仅在于细菌再次生长的时间间隔，其顺序如下：CFS、CPZ、CTZ和CPM。这一发现证实了头孢匹胺的药代动力学特性使得给药间隔时间比其他药物更宽。
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