Mach T
Pol J Pharmacol Pharm. 1986 May-Jun;38(3):235-41.
This study was aimed to examine whether disulfiram (DS) may exacerbate the pre-existing liver damage induced by D-galactosamine (GalN) in rats. DS, 600 mg/kg, administered by gavage for 3 days caused an increase in asparagine aminotransferase (AspAT) and alkaline phosphatase (AP) and a decrease in cholinesterase (ChE) activity in the serum and decrease in AspAT and ChE activity in the liver. DS given to rats with GAlN-induced liver injury caused significant increase in alanine aminotransferase (A1AT) and bilirubin level in serum in comparison with rats with GalN-damaged liver but without DS treatment. In summary, DS exacerbates a damage of the liver of rats. This study supported the clinical observations showing enhanced liver damage in alcoholics treated with DS.
本研究旨在探讨双硫仑（DS）是否会加重大鼠体内由D-半乳糖胺（GalN）诱导的原有肝损伤。以600mg/kg的剂量通过灌胃给予DS，持续3天，导致血清中天冬氨酸转氨酶（AspAT）和碱性磷酸酶（AP）升高，胆碱酯酶（ChE）活性降低，肝脏中AspAT和ChE活性也降低。给予GalN诱导肝损伤的大鼠DS后，与未接受DS治疗的GalN损伤肝脏大鼠相比，血清中丙氨酸转氨酶（A1AT）和胆红素水平显著升高。总之，DS会加重大鼠肝脏损伤。本研究支持了临床观察结果，即接受DS治疗的酗酒者肝损伤加重。
