Rao Wei-Hao, Jiang Li-Li, Liu Xiao-Meng, Chen Mei-Jun, Chen Fang-Yuan, Jiang Xin, Zhao Jin-Xiao, Zou Guo-Dong, Zhou Yu-Qiang, Tang Lin
College of Chemistry and Chemical Engineering , Xinyang Normal University , Xinyang 464000 , China.
Henan Key Laboratory of Utilization of Non-Metallic Mineral in the South of Henan , Xinyang Normal University , Xinyang 464000 , China.
Org Lett. 2019 Apr 19;21(8):2890-2893. doi: 10.1021/acs.orglett.9b00907. Epub 2019 Apr 8.
A copper-catalyzed direct aminosulfonylation of unactivated alkenes with sodium sulfinates for the efficient synthesis of sulfonylated pyrrolidones is described. This reaction features good functional group tolerance and wide substrate scope, providing an efficient and straightforward protocol to access this kind of pyrrolidones. Moreover, preliminary mechanistic investigations disclosed that a free-radical pathway might be invovled in the process.
描述了一种铜催化未活化烯烃与亚磺酸钠的直接氨磺酰化反应，用于高效合成磺酰化吡咯烷酮。该反应具有良好的官能团耐受性和广泛的底物范围，为获得这类吡咯烷酮提供了一种高效且直接的方法。此外，初步的机理研究表明该过程可能涉及自由基途径。
