Department of Immunopathology, Sanquin Research, Amsterdam, the Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Department of Immunopathology, Sanquin Research, Amsterdam, the Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands.
Immunol Lett. 2019 May;209:45-52. doi: 10.1016/j.imlet.2019.03.014. Epub 2019 Apr 5.
The anaphylatoxin C5a is well-known for its role as chemoattractant and contributes to immune cell recruitment into inflamed tissue and local inflammation. C5a has recently been implicated in modulation of antigen presenting cell function, such as macrophages and dendritic cells, which are pivotal for T cell activation and final T cell effector function. The published data on the effect of C5a on APC function and subsequent adaptive immune responses are in part conflicting, as both pro and anti-inflammatory effects have been described. In this review the opposing effects of C5a on APC function in mice and human are summarized and discussed in relation to origin of the involved APC subset, being either of the monocyte-derived lineage or dendritic cell lineage. In addition, the current knowledge on the expression of C5aR1 and C5aR2 on the different APC subsets is summarized. Based on the combined data, we propose that the differential effects of C5a on APC function may be attributed to absence or presence of co-expression of C5aR2 and C5aR1 on the specific APC.
过敏毒素 C5a 是众所周知的趋化因子，有助于免疫细胞募集到炎症组织和局部炎症部位。C5a 最近被牵连到抗原呈递细胞（APC）功能的调节，如巨噬细胞和树突状细胞，这对于 T 细胞激活和最终 T 细胞效应功能至关重要。关于 C5a 对 APC 功能和随后的适应性免疫反应的影响的已发表数据在一定程度上存在冲突，因为既描述了抗炎作用，也描述了促炎作用。在这篇综述中，总结了 C5a 在小鼠和人类 APC 功能上的相反作用，并与所涉及的 APC 亚群的起源相关联，这些亚群要么来自单核细胞衍生谱系，要么来自树突状细胞谱系。此外，还总结了目前关于 C5aR1 和 C5aR2 在不同 APC 亚群上表达的知识。基于综合数据，我们提出 C5a 对 APC 功能的不同影响可能归因于特定 APC 上 C5aR2 和 C5aR1 的共表达缺失或存在。
