Deleo V A, Hanson D, Scheide S
Toxicol Lett. 1986 Sep;32(3):215-20. doi: 10.1016/0378-4274(86)90110-4.
Benoxaprofen (BPF) induces a clinical photosensitivity which resembles idiopathic solar urticaria. This response is mediated by degranulation of mast cells. Since mast-cell degranulation is known to be modulated by phospholipid alteration, we examined the effect of BPF and ultraviolet radiation (UV) on phospholipid metabolism of C3H 10 T1/2 cells in culture. BPF + UVB (280-320 nm) induced release of [3H]arachidonic acid (AA) but did not alter the release of [3H]choline from prelabelled cells. This suggests that BPF photosensitizes phospholipase A2 activation. Such activation probably represents an integral step in the mechanism of BPF photosensitization of mast-cell degranulation.
苯恶洛芬（BPF）可引发一种类似于特发性日光性荨麻疹的临床光敏反应。这种反应是由肥大细胞脱颗粒介导的。由于已知肥大细胞脱颗粒受磷脂变化的调节，我们研究了BPF和紫外线辐射（UV）对培养的C3H 10 T1/2细胞磷脂代谢的影响。BPF + 中波紫外线（UVB，280 - 320纳米）诱导了[3H]花生四烯酸（AA）的释放，但未改变预标记细胞中[3H]胆碱的释放。这表明BPF使磷脂酶A2激活产生光敏作用。这种激活可能是BPF使肥大细胞脱颗粒发生光敏作用机制中的一个重要步骤。
