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评价药师在跨学科住院心力衰竭咨询服务中的影响。

Evaluation of Pharmacist Impact Within an Interdisciplinary Inpatient Heart Failure Consult Service.

机构信息

1 James A. Haley Veterans' Hospital, Tampa, FL, USA.

2 Nova Southeastern University College of Pharmacy, Davie, FL, USA.

出版信息

Ann Pharmacother. 2019 Sep;53(9):905-915. doi: 10.1177/1060028019842656. Epub 2019 Apr 9.

Abstract

Heart failure (HF) is highly prevalent in the Veterans Affairs (VA) health care system and the leading cause of hospital discharges in the VA. Despite guideline-specific recommendations of drug therapy, many patients are not on optimal medication regimens. To examine and quantify pharmacist impact in an interdisciplinary HF consult (IC) service on increasing use of guideline-directed medical therapy (GDMT). The 30-day readmission rates before and after the implementation of an IC service are reported. This was a single-center retrospective analysis of veterans admitted with a HF diagnosis between August 2008 and August 2015 in 2 distinctive cohorts: pre-IC (August 2008 to November 2011) and IC (November 2011 to August 2015). Four-hundred patients were included, with 200 in each cohort. All-cause readmissions at 30 days were not different between pre-IC and IC groups: 33.5% versus 28.5%, respectively. Secondary outcomes of HF readmission and 1-year mortality were not different between groups. Significant increases in medication use rates were observed from admission to discharge in both cohorts; however, greater increases were observed in the IC group in which the pharmacist role was clearly defined in recommending GDMT optimization, especially in patients with HF with reduced ejection fraction. Although the implementation of an IC service did not significantly change 30-day readmission rates, increases in GDMT use are evident with increased pharmacist involvement. Longer-term outcomes associated with this intervention warrant future investigation.

摘要

心力衰竭(HF)在退伍军人事务部(VA)医疗保健系统中患病率很高,也是 VA 医院出院的主要原因。尽管有特定指南的药物治疗建议,但许多患者并未使用最佳的药物治疗方案。本研究旨在评估和量化药剂师在跨学科心力衰竭咨询(IC)服务中对增加使用指南指导的药物治疗(GDMT)的影响。报告了实施 IC 服务前后 30 天再入院率。这是一项单中心回顾性分析,纳入了 2008 年 8 月至 2015 年 8 月期间因心力衰竭住院的退伍军人,分为两个不同队列:IC 前(2008 年 8 月至 2011 年 11 月)和 IC 后(2011 年 11 月至 2015 年 8 月)。共纳入 400 例患者,每组 200 例。IC 前组和 IC 组的 30 天全因再入院率分别为 33.5%和 28.5%,两组间无差异。HF 再入院和 1 年死亡率的次要结局在两组间也无差异。两个队列中,从入院到出院,药物使用率均显著增加;然而,在明确规定药剂师在推荐 GDMT 优化方面作用的 IC 组中,药物使用增加幅度更大,特别是在射血分数降低的心力衰竭患者中。尽管实施 IC 服务并未显著改变 30 天再入院率,但随着药剂师参与度的增加,GDMT 的使用明显增加。需要进一步研究该干预措施的长期结局。

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