Malvin G M, Hlastala M P
Am J Physiol. 1986 Nov;251(5 Pt 2):R941-6. doi: 10.1152/ajpregu.1986.251.5.R941.
The effects of lung O2 and CO2 content and volume on cutaneous gas exchange and perfusion were investigated in the frog, Rana pipiens. (Ha)-anesthetized frogs were equilibrated with 9.5% Freon-22 (Fr, chlorodifluoromethane) and 1.1% Ha. Cutaneous elimination of Fr, Ha, and CO2 into a small sample chamber on the abdomen was measured with a mass spectrometer. Introducing an air mixture into the lung decreased cutaneous Fr, Ha, and CO2 elimination. Lung inflation with an O2 mixture decreased cutaneous gas elimination more than with the air mixture. Inflation with a N2 mixture had no effect. The response to lung inflation with the air mixture was not affected by adding 4.8% CO2 to the air mixture or by atropine. Voluntary lung ventilation decreased CO2 and Fr elimination. The results indicate that intrapulmonary O2 is a factor regulating skin breathing. If a change in lung volume is also a factor, it requires a concomitant change in lung O2. Intrapulmonary CO2 and cholinergic nerves are not involved in cutaneous respiration across the abdomen.
在牛蛙（Rana pipiens）中研究了肺内氧气、二氧化碳含量及容量对皮肤气体交换和灌注的影响。用（哈）麻醉的青蛙用9.5%的氟利昂 - 22（Fr，二氯二氟甲烷）和1.1%的哈平衡。用质谱仪测量腹部小样品室中皮肤对Fr、哈和二氧化碳的排出量。向肺内引入空气混合物会减少皮肤对Fr、哈和二氧化碳的排出。用氧气混合物使肺膨胀比用空气混合物使皮肤气体排出减少得更多。用氮气混合物膨胀肺没有影响。向空气混合物中添加4.8%的二氧化碳或使用阿托品不会影响对空气混合物使肺膨胀的反应。自主肺通气会减少二氧化碳和Fr的排出。结果表明，肺内氧气是调节皮肤呼吸的一个因素。如果肺容量的变化也是一个因素，那么它需要伴随着肺内氧气的变化。肺内二氧化碳和胆碱能神经不参与腹部皮肤的呼吸作用。
