[手术与获得性凝血因子 VIII 抑制剂]

[Surgery and the acquired inhibitor of factor VIII coagulant].

作者信息

Vivin P, Helmer J, Kipper R, Thome M, Briquel M E

出版信息

Ann Fr Anesth Reanim. 1986;5(3):322-5. doi: 10.1016/s0750-7658(86)80166-6.

Abstract

A case is reported of an 80 year old woman with old sarcoidosis and acquired factor VIIIc inhibitor undergoing orthopaedic surgery. This was successfully carried out after she had been given a total of 48,420 units of factor VIII concentrate: there were no haemorrhagic complications. The main pathological states in which acquired factor VIIIc inhibitor may be found are related: principal treatments available nowadays are discussed: immunosuppressors, human factor VIII, animal factor VIII, prothrombin complex concentrate, plasma exchange.

摘要

报告了一例80岁患有陈旧性结节病并获得性凝血因子VIIIc抑制物的女性接受骨科手术的病例。在给予她总计48420单位的凝血因子VIII浓缩物后，手术成功进行：未出现出血并发症。可发现获得性凝血因子VIIIc抑制物的主要病理状态相关：讨论了目前可用的主要治疗方法：免疫抑制剂、人凝血因子VIII、动物凝血因子VIII、凝血酶原复合物浓缩物、血浆置换。