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拓展干扰素基因刺激蛋白（STING）在细胞内稳态和细胞转化中的作用

Expanding the Role of STING in Cellular Homeostasis and Transformation.

作者信息

Li Jun, Bakhoum Samuel F

机构信息

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

出版信息

Trends Cancer. 2019 Apr;5(4):195-197. doi: 10.1016/j.trecan.2019.02.001. Epub 2019 Feb 23.

DOI:10.1016/j.trecan.2019.02.001
PMID:30961826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8290631/
Abstract

The cytosolic DNA-sensing cGAS-STING pathway was originally characterized as a key innate immune mediator responsible for the induction of antiviral genes in response to foreign DNA species in the cytosol. Mounting evidence, however, points to a complex role for cGAS and STING in cancer. Two recent reports, by Ranoa et al. (Cancer Research, 2018;https://doi.org/10.1158/0008-5472.CAN-18-1972) and Nassour et al. (Nature 2019;565:659-663), dissect the function of this pathway during the early steps of cellular transformation and shed light on the complexity and context-dependence of cGAS-STING signaling in cancer.

摘要

胞质DNA感应cGAS-STING通路最初被认为是一种关键的固有免疫介质，负责在细胞质中感应外来DNA种类时诱导抗病毒基因。然而，越来越多的证据表明cGAS和STING在癌症中发挥着复杂的作用。Ranoa等人（《癌症研究》，2018年；https://doi.org/10.1158/0008-5472.CAN-18-1972）和Nassour等人（《自然》，2019年；565:659-663）最近的两项报告剖析了该通路在细胞转化早期阶段的功能，并揭示了癌症中cGAS-STING信号传导的复杂性和背景依赖性。

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本文引用的文献

1
Autophagic cell death restricts chromosomal instability during replicative crisis.
Nature. 2019 Jan;565(7741):659-663. doi: 10.1038/s41586-019-0885-0. Epub 2019 Jan 23.
2
An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer.
Mol Ther Nucleic Acids. 2019 Mar 1;14:80-89. doi: 10.1016/j.omtn.2018.11.003. Epub 2018 Nov 20.
3
STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability.
Cancer Res. 2019 Apr 1;79(7):1465-1479. doi: 10.1158/0008-5472.CAN-18-1972. Epub 2018 Nov 27.
4
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
Nature. 2018 Nov;563(7729):131-136. doi: 10.1038/s41586-018-0629-6. Epub 2018 Oct 24.
5
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
Mol Cell. 2018 Sep 6;71(5):745-760.e5. doi: 10.1016/j.molcel.2018.07.034.
6
Chromosomal instability drives metastasis through a cytosolic DNA response.
Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.
7
Host STING-dependent MDSC mobilization drives extrinsic radiation resistance.
Nat Commun. 2017 Nov 23;8(1):1736. doi: 10.1038/s41467-017-01566-5.
8
Cytoplasmic chromatin triggers inflammation in senescence and cancer.
Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.
9
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Nature. 2017 Aug 24;548(7668):466-470. doi: 10.1038/nature23470. Epub 2017 Jul 31.
10
cGAS surveillance of micronuclei links genome instability to innate immunity.
Nature. 2017 Aug 24;548(7668):461-465. doi: 10.1038/nature23449. Epub 2017 Jul 24.

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