Department of Clinical Laboratory, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Cell Cycle. 2023 Jan;22(1):38-56. doi: 10.1080/15384101.2022.2109899. Epub 2022 Aug 10.
The cGAS/STING signaling pathway is an important part of the cytoplasmic DNA sensor, which can trigger a type I interferon response to microbial infection when pathogenic DNA is detected. However, continuous inhibition of cGAS/STING signaling by viral infection may be an important cause of tumorigenesis. At the same time, recent studies have shown that although the cGAS/STING signaling pathway also plays a core role in anti-tumor immunity and cell senescence, the inflammatory response induced by cGAS/STING signaling will also promote tumorigenesis in different backgrounds. Here, we discuss the role of cGAS/STING in the context of infection, senescence, and tumors, especially with respect to progression, to facilitate a better understanding of the mechanism of the cGAS/STING pathway.
cGAS/STING 信号通路是细胞质 DNA 传感器的重要组成部分，当检测到病原 DNA 时，它可以触发 I 型干扰素反应以抵抗微生物感染。然而，病毒感染持续抑制 cGAS/STING 信号可能是肿瘤发生的一个重要原因。同时，最近的研究表明，尽管 cGAS/STING 信号通路在抗肿瘤免疫和细胞衰老中也起着核心作用，但 cGAS/STING 信号诱导的炎症反应也会在不同背景下促进肿瘤发生。在这里，我们讨论了 cGAS/STING 在感染、衰老和肿瘤中的作用，特别是在进展方面，以促进更好地理解 cGAS/STING 通路的机制。
