Gallimard J F, Chaix A F, Allal J, Thomas P, Poupet J Y, Barraine R
Arch Mal Coeur Vaiss. 1986 Jun;79(7):1054-60.
Ultrasonic investigations of the peripheral vessels (continuous Doppler with spectral analysis, echotomography) were performed to evaluate atherosclerosis of the main arteries (abdominal aorta, cervical arteries, lower limb arteries) in 50 coronary patients and 40 control subjects. In the main, our results support those of previously published series (epidemiological and autopsy studies): Atherosclerosis of the main arterial vessels is significantly more common (p less than 0.01) in coronary patients than in control subjects: carotid lesions: 70% (including 10% with severe stenosis) compared to 32% (no severe stenosis); aortic lesions: 50% (including 20% with severe stenosis) compared to 17.5% (7.5% severe stenosis); lower limb arteries: 58% (including 16% severe stenosis) compared to 12.5% (no severe stenosis). The difference of incidences of associations of atherosclerosed vessels between the two groups was significant (p less than 0.01): no peripheral vascular disease was detected in 57.5% of controls compared to only 12% of coronary patients; more than one territory diseased in 15% of controls compared to 58% of coronary patients. The severity of these lesions correlated with the presence of the three major cardiovascular risk factors which were studied (hypertension, smoking, hypercholesterolaemia) and was significantly higher (p less than 0.01) in coronary patients (38% had more than one major risk factor and only 10% had none) than in controls (47% had no risk factors and 6% had more than one). In addition, the preferential sites of atherosclerosis were also confirmed.(ABSTRACT TRUNCATED AT 250 WORDS)
对50例冠心病患者和40例对照者进行了外周血管的超声检查(连续多普勒频谱分析、超声断层扫描),以评估主要动脉(腹主动脉、颈动脉、下肢动脉)的动脉粥样硬化情况。总体而言,我们的结果支持先前发表的系列研究(流行病学和尸检研究)结果:主要动脉血管的动脉粥样硬化在冠心病患者中比对照者明显更常见(p<0.01):颈动脉病变:70%(包括10%重度狭窄),而对照者为32%(无重度狭窄);主动脉病变:50%(包括20%重度狭窄),对照者为17.5%(7.5%重度狭窄);下肢动脉:58%(包括16%重度狭窄),对照者为12.5%(无重度狭窄)。两组间动脉粥样硬化血管联合发生率的差异具有显著性(p<0.01):57.5%的对照者未检测到外周血管疾病,而冠心病患者仅为12%;15%的对照者有一个以上区域病变,而冠心病患者为58%。这些病变的严重程度与所研究的三大心血管危险因素(高血压、吸烟、高胆固醇血症)的存在相关,且在冠心病患者中显著更高(p<0.01)(38%有一个以上主要危险因素,仅10%无危险因素),高于对照者(47%无危险因素,6%有一个以上危险因素)。此外,动脉粥样硬化的好发部位也得到了证实。(摘要截短于250字)